产品信息
[产品供应]

Monoclonal Anti-cAMP Antibody Based Direct cAMP ELISA Kit

产品货号: 80203
供应商: 武汉纽斯特生物技术有限公司
产品产地: USA
商标: neweast
品牌: neweast
参考价格: 询价
销售区域: 全国
使用范围: 仅为制药设备或原料、科研使用,不能直接做用于人
产品参数
产品名: Monoclonal Anti-cAMP Antibody Based Direct cAMP ELISA Kit
英文名: Monoclonal Anti-cAMP Antibody Based Direct cAMP ELISA Kit 
销售分类: G蛋白系列—G蛋白单抗和多抗 > G蛋白多抗 型号/货号: 80203
产地: USA 商标: neweast
销售地区: 全国 价格: 询价
产品特性: Monoclonal Anti-cAMP Antibody Based Direct cAMP ELISA Kit (New Non-acetylated Version) Catalog No. 80203 96 Well Kit
信息有效期: [长期有效]    [更新时间:2017-2-9 12:43:02 ]
制药在线声明:以上所展示的信息由企业自行提供,内容的真实性、准确性和合法性由发布企业负责。制药在线对此不承担任何保证责任。

Monoclonal Anti-cAMP Antibody Based
Direct cAMP ELISA Kit
(New Non-acetylated Version)
Catalog No. 80203
96 Well Kit

Product Description
Adenosine 3', 5'-cyclic monophosphate (cyclic AMP; cAMP) modulates various physiological functions
such as cardiovascular biology, learning and memory, olfaction, immune response, asthma and kidney
function (1,2). cAMP is produced from ATP by adenylyl cyclases and is degraded by
phosphodiesterases. Stimulation of adenylyl cyclases or inhibition of phosphodiesterases can increase
cellular cAMP concentrations. Blockers of adenylyl cyclase-activating receptors and inhibitors of the
cAMP-specific phosphodiesterases are used for treating human diseases. For example, blocking agents
for cAMP-increasing beta-adrenergic receptors (beta-blockers) are used for
treating abnormal heart rhythms, high blood pressure (hypertension),
myocardial infarction and heart failure. Inhibitors of cAMP specific
phosphodiesterase types 2 and 4 are being tested for cognition
enhancement.
To screen for inhibitors or stimulators of cellular cAMP levels, it is
essential to have a sensitive, selective and reproducible method to measure
the cAMP concentrations. This is especially true for the initial screenings
given the possible weaker effects of larger pools of compounds.
Currently available other ELISA kits measuring cAMP levels are based on
the non-affinity-purified polyclonal anti-cAMP antibody. Despite the
claimed selectivity, these polyclonal anti-cAMP antibodies display certain
cross-reactivity with ATP. Given that ATP is the substrate for the cAMP production, it is very desirable
to have an antibody with high specificity towards cAMP over ATP.
NewEast Biosciences cAMP ELISA kit is based on the unique mouse monoclonal anti-cAMP
antibody. This monoclonal anti-cAMP antibody displays >108 fold of selectivity over ATP, cGMP, and
other nucleoside analogues. NewEast Biosciences cAMP ELISA kit provides significantly improved
sensitivity and selectivity over other kits based on polyclonal anti-cAMP antibodies. Our monoclonal
anti-cAMP antibody-based ELISA kit also avoids the batch-to-batch variations associated with
polyclonal antibody productions from animals, thus providing the reproducibility in the long run.
Furthermore, while polyclonal anti-cAMP antibodies used in other ELISA kits have higher affinity for
acetylated cAMP than non-acetylated cAMP, NewEast Biosciences monoclonal anti-cAMP antibody has
similar affinities to non-acetylated and acetylated cAMP molecules. Therefore, acetylation treatments of
samples and standards are not needed in NewEast Biosciences cAMP ELISA kit. This significantly
reduces the time for the assay. The avoidance of organic reagents used in the acetylation process
provides a safe and healthy work environment.

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